Publication from our partner Politecnico di Milano

We’re pleased to share a publication from our partner Politecnico di Milano, now featured in Biofabrication:

A novel solution for real-time in-situ cell distribution monitoring in 3D bioprinting via fluorescence imaging - IOPscience

In this study, researchers introduce a real-time, in-situ monitoring system that tracks how cells are distributed throughout the layers of 3D-bioprinted structures—as the printing happens. By tagging cells with fluorescent nanoparticles and integrating a compact imaging system into the bioprinter, the team enables more precise quality control of tissue constructs.

Why does this matter for BioProS?

Because it brings us closer to using cells as real-time biosensors—detecting, responding to, and even reporting on viral presence or changes in their environment, right inside living systems. It’s a step forward for biofabrication, reliability, and biosensing.

Images of each layer of portion of Step 4 construct. From top to bottom are present: images captured in visible field with Dino-Lite digital microscope; images captured in fluorescence with Dino-Lite digital microscope; result of the binarisation using Otsu method of the images in fluorescence; Heatmap of the cell distribution in each layer.